Cedars-Sinai Research Associate III in Los Angeles, California
Requisition #: 28291
Working Title: Research Associate III
Business Entity: CSMC - Cedars-Sinai Medical Center
Cost Center # - Cost Center Name: 0801103 - Home Dept - Pulmonary
City: Los Angeles
Job Category: Research/Research Admin
Job Specialty: Research
Position Type: Regular-F/T
Shift Length: 8hr
Hours: 8:30am - 5pm
Days: Monday - Friday
Shift Type: Day
Job Posting: Summary of Essential Job Duties:
The Sutterwala and Cassel Laboratory is a joint lab led by Fayyaz Sutterwala, MD, PhD, director of the Infectious Diseases Division, and Suzanne Cassel, MD, assistant professor in Pulmonary and Critical Care. The focus of studies in the Sutterwala and Cassel Lab is a family of cytosolic molecules called nucleotide-binding domain leucine-rich repeat containing receptors (NLRs) that are involved in the regulation of innate immune responses and cell death pathways. Some NLR family members promote the activation of pro-inflammatory caspases within multiprotein complexes called inflammasomes. Mutations within NLRP3, a member of the NLR family, have been linked to a group of autoinflammatory disorders in humans collectively known as the cryopyrin-associated periodic syndromes. NLRC4, another NLR family member, has been shown to play a crucial role in response to infection with a number of gram-negative bacteria. To understand the role of NLRs in coordinating the immune response, we have used a gene-targeting approach utilizing mice deficient in specific inflammasome components. The Sutterwala and Cassel Lab is interested in defining the molecular mechanisms by which inflammasomes are activated and their role in host defense against a variety of pathogens. We are also interested in how inflammasomes can exacerbate inflammatory responses to sterile inflammatory insults such as ischemia as well as inhaled environmental pollutants.
Under general guidance, the Research Associate III works closely with PI, providing technical and/or administrative support. Will have specific supervisory activities, and provide administrative leadership, and/or technical expertise. May develop hypothesis and assist in planning steps for the investigative process. Will review and remain current on literature as it relates to research study. May be co-author or author of publications and make independent presentations. Will assist in planning steps for the investigative process. Will coordinate all lab activities, including but not limited to, budgetary/financial compliance, preparation of grant proposals, and creating independent presentations. May perform the duties of the Research Associate I or II, and must have a thorough understanding of laboratory and research functions. Will supervise and train other Research Laboratory Assistants and Research Associates. Not responsible for generating grant funds.
ESSENTIAL JOB DUTIES AND RESPONSIBILITIES:
Participates in project planning, troubleshooting and execution of research projects.
Provides miscellaneous research support (experimental design, troubleshooting, data analysis, etc.) to other lab members.
Monitors and ensures compliance with safety standards and procedures.
Analyzes data and prepares scientific findings for publication as co-author.
Makes independent presentations.
Manages day-to-day activities of lab including ordering of supplies and monitoring inventory to ensure efficient functioning
Supervises and trains new lab members, Research Lab Assistants, Research Associates, and Postdoctoral researchers. Orients new individuals to the day-to-day operations and laboratory procedures.
DEPARTMENT AND/OR UNIT SPECIFIC – ESSENTIAL JOB RESPONSIBILITIES:
Organize and maintain structure of the lab, managing day-to-day activities
Develop, implement and maintain laboratory guidelines and standard operating procedures
Ensure supply inventory is adequate and act as primary resource for purchasing, managing vendor relationships
Train and supervise research assistants and post-docs and coordinate their involvement in daily lab tasks and research projects, including experimental design, trouble-shooting, and analysis
Orient and train all personnel on lab safety, conduct, standards, and technical and administrative practices
Design, perform, and analyze in vivo and in vitro immunology experiments
Serve as lab emergency contact, and enforce compliance with safety and lab procedures among all lab personnel
Attend and participate in regular laboratory meetings
Assist with preparation of grant proposals, publications and presentations
Oversee and maintain lab mouse colony with appropriate documentation, write and maintain animal protocols, ensure compliance of all lab members with safety and animal welfare regulations, and liaise between the lab and the Institutional Animal Care and Use Committee and the Comparative Medicine staff
Education Certifications/Licensure Experience Physical Abilities Educational Requirements:
Bachelor of Science Degree, required. Master of Science Degree, preferred.
Three to five (3-5) years of experience in immunology or related research. Experience in molecular/cellular biology techniques including Western blot, ELISA, PCR, quantitative real-time PCR, sub-cloning, immunoprecipitation. Experience with in vivo mouse models. Strong computer skills (MS Word, MS Excel, PowerPoint). Strong analytical and problem-solving skills; excellent organization skills and very detail-oriented; learns new tasks quickly; self-motivated; works well independently with minimal supervision; works well with others, and able to multitask. Strong interpersonal skills for interaction with peers and other members of the medical center. Thorough technical and theoretical understanding of PI’s research objectives. Mastery of complex or unusual technical procedures and protocols. Ability to research, develop, and implement new laboratory procedures and protocols. Knowledge of human resource and administration policies and procedures. Knowledge of budgetary requirements and policies.
Experience with immunology research preferred
Experience with management of mouse colony preferred
Supervisory and team management experience preferred
Ability to tolerate exposure to mouse allerens. Able to perform moderate lifting (up to 30 pounds). Able to sit, stand and walk for prolonged periods of time. Able to read papers and online documents. Able to operate standard office equipment. Able to exercise physical ability and perspective acuity to satisfactorily perform essential job functions.
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Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.
Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.